Reproducibility of Tumor Perfusion Measurements Using 15O-Labeled Water and PET
نویسندگان
چکیده
منابع مشابه
Reproducibility of tumor perfusion measurements using 15O-labeled water and PET.
UNLABELLED PET and 15O-labeled water (H215O) can be used to noninvasively monitor tumor perfusion. This allows evaluation of the direct target of antiangiogenic drugs, that is, tumor vasculature. Because these drugs often result in consolidation rather than regression of the tumor mass, a change in perfusion might be a more sensitive way to evaluate response than are indirect size measures on a...
متن کاملReproducibility of tumor blood flow quantification with 15O-water PET.
UNLABELLED Noninvasive methods for quantifying tumor blood flow (TBF) have a potentially important role in the field of drug development. (15)O-water PET has been used in several studies aimed at monitoring response to novel treatments. Assessing the significance of changes in TBF requires knowledge of the reproducibility of the technique. This article quantifies the reproducibility of the (15)...
متن کاملQuantification of subendocardial and subepicardial blood flow using 15O-labeled water and PET: experimental validation.
UNLABELLED The purpose of this study was to assess the feasibility and accuracy of quantifying subendocardial and subepicardial myocardial blood flow (MBF) and the relative coronary flow reserves (CFR) using (15)O-labeled water (H(2)(15)O) and 3-dimensional-only PET. METHODS Eight pigs were scanned with H(2)(15)O and (15)O-labeled carbon monoxide (C(15)O) after partially occluding the circumf...
متن کاملDiagnosis of misery perfusion using noninvasive 15O-gas PET.
UNLABELLED To avoid arterial blood sampling and complicated analyses in 15O-gas PET studies, we evaluated a noninvasive technique using the count-based method for measuring asymmetric increases in oxygen extraction fraction (OEF) in cerebrovascular disease. METHODS Eighteen patients (mean age +/- SD, 61 +/- 16 y) with atherothrombotic large-cerebral-artery disease were studied for the measure...
متن کاملFeasibility of subendocardial and subepicardial myocardial perfusion measurements in healthy normals with 15O-labeled water and positron emission tomography
BACKGROUND Positron emission tomography (PET) enables robust and reproducible measurements of myocardial blood flow (MBF). However, the relatively limited resolution of PET till recently prohibited distinction between the subendocardial and the subepicardial layers in non-hypertrophied myocardium. Recent developments in hard- and software, however, have enabled to identify a transmural gradient...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2008
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.108.053454